Role of cytokines in inflammatory bowel disease

查看全文 作　　者：Fausto Sanchez-Mu[1]oz;Aaron Dominguez-[1]Lopez;Jesus K Yamamoto-[1]Furusho

机构地区：[1]Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15 colonia Sección XVI

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第27期,共9页

摘　　要：Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), rep- resents a group of chronic disorders characterized by inflammation of the gastrointestinal tract, typically with a relapsing and remitting clinical course. Mucosal mac- rophages play an important role in the mucosal im- mune system, and an increase in the number of newly recruited monocytes and activated macrophages has been noted in the inflamed gut of patients with IBD. Activated macrophages are thought to be major con- tributors to the production of inflammatory cytokines in the gut, and imbalance of cytokines is contributing to the pathogenesis of IBD. The intestinal inflammation in IBD is controlled by a complex interplay of innate and adaptive immune mechanisms. Cytokines play a key role in IBD that determine T cell differentiation of Th1, Th2, T regulatory and newly described Th17 cells. Cytokines levels in time and space orchestrate the development, recurrence and exacerbation of the inflammatory process in IBD. Therefore, several cyto- kine therapies have been developed and tested for the treatment of IBD patients. 关键词：克罗恩氏病肠炎消化道疾病消化功能紊乱

相关文献

参考文献（100）
引证文献（81）
耦合文献（10）

参考文献(100)

引证文献(81)

耦合文献(10)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Role of cytokines in inflammatory bowel disease

参考文献(100)

引证文献(81)

耦合文献(10)

用户提示