Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain

查看全文 作　　者：Jun-Ming ZHANG Judith A. [1]Strong

机构地区：[1]Department of Anesthesiology, University of Cincinnati College of Medicine 231 Albert Sabin Way, Cincinnati, OH 45267-0531, USA

出　　处：《生理学报》索引2008年第60卷第5期,共11页

摘　　要：Traumatic injury or inflammatory irritation of the peripheral nervous system often leads to persistent pathophysiological pain states.It has been well-documented that,after peripheral nerve injury or inflammation,functional and anatomical alterations sweep over the entire peripheral nervous system including the peripheral nerve endings,the injured or inflamed afferent fibers,the dorsal root ganglion(DRG),and the central afferent terminals in the spinal cord.Among all the changes,ectopic discharge or spontaneous activity of primary sensory neurons is of great clinical interest,as such discharges doubtless contribute to the develop-ment of pathological pain states such as neuropathic pain.Two key sources of abnormal spontaneous activity have been identified following peripheral nerve injury:the injured afferent fibers(neuroma) leading to the DRG,and the DRG somata.The purpose of this review is to provide a global account of the abnormal spontaneous activity in various animal models of pain.Particular attention is focused on the consequence of peripheral nerve injury and localized inflammation.Further,mechanisms involved in the generation of spontaneous activity are also reviewed;evidence of spontaneous activity in contributing to abnormal sympathetic sprouting in the axotomized DRG and to the initiation of neuropathic pain based on new findings from our research group are discussed.An improved understanding of the causes of spontaneous activity and the origins of neuropathic pain should facilitate the development of novel strategies for effective treatment of pathological pain. 关键词：活动依赖性神经性疼痛病症临床分析

相关文献

参考文献（124）
引证文献（10）
耦合文献（6）

参考文献(124)

引证文献(10)

耦合文献(6)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain

参考文献(124)

引证文献(10)

耦合文献(6)

用户提示