Preparation of 5-Fluorouracil Loaded Polylactide-co-glycolide-co-methoxy Poly(ethylene glycol) (PLGA-mPEG) Nanoparticles via High Speed Shearing

查看全文 作　　者：LIN [1]Hang;REN [2]Hui;WANG Xi-[3]shan;TANG Qing-[3]chao;TANG [1]Jun;WANG [1]Ce 机构地区：[1]College of Chemistry, Alan G. MacDiarmid Institute, Jilin University, Changchun 130012, P. R. China;[2]Department of General Surgery, the Second Hospital, Jilin University, Changchun 130023, P. R. China;[3]Department of Abdominal Surgery, the Affiliated Tumor Hospital, Harbin Medical University, Harbin 150081, P. R. China 出　　处：《Chemical Research in Chinese Universities》索引2008年第24卷第6期,共4页 基　　金：Supported by the National Natural Basic Research Program of China(No. 2007CB80800);the Special Foundation of Harbin Technical Innovation for Talental Person(No. 2006RFQXS075) 摘　　要：5-Fluorouracil(5-FU) loaded nanoparticles(NPs) were prepared by a high speed shearing double emulsion method with polylactide-co-glycolide-co-methoxy poly(ethylene glycol)(PLGA-mPEG) as loading material. The prepared NPs possess a negative zeta potential and their loading efficiency is about 15%(mass fraction). The result of in vitro release shows that the release behavior of 5-FU from NPs is coincident with Zero-level release from the second day. 关 键 词：纳米颗粒 氟尿嘧啶 聚交酯 乙烯