Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in Han and Jinuo populations in Yunnan Province,southwest of China

查看全文 作　　者：Yufeng Yao 1, Li Shi 1, Lei Shi, Keqin Lin, Yufen Tao, Liang Yu, Hao Sun, Xiaoqin Huang, Yanhan Li, Jiayou Chu Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China

出　　处：《Journal of Genetics and Genomics》索引2009年第36卷第1期,共8页

基　　金：supported by China Medical Board (No. 04-805). 摘　　要：The associations of polymorphic Alu insertions (POALINs) with major histocompatibility complex (MHC) class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populations. For further studying origins and evolution of MHC class I region haplotypes in Han and Jinuo populations in Yunnan Province, we investigated frequencies of five POALINs, their associations with HLA-A and -B, the three-loci POALINs haplotype frequencies and HLA/POALIN four-loci haplotype frequencies within the alpha block of MHC class I region. We found that a strong positive association between AluHG and HLA-A*02 is in Jinuo, but not in Yunnan Han. These results suggest that MHC class I region haplotypes of the two studied populations might derive from different progenitor haplotypes and MHC I-POALINs are informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in different populations. 关键词：遗传学单模标本 MHCI 方法研究

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Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in Han and Jinuo populations in Yunnan Province,southwest of China

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