MicroRNA expression profiles and functions in the brain

查看全文 作　　者：Yanting [1]Qi;Yu [1]Zhao;Zhuyin [2]Chen;Xiaona [1]Chen;Marie C. [3]Lin;Xiangfu [2]Kong;Lihui [1]Lai 机构地区：[1]Institute of Molecular and Chemical Biology, East China Normal University, Shanghai 200062, China;[2]Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SpecialAdministrative Region, China;[3]Department of Chemistry, Open Laboratory of Chemical Biology, University of Hong Kong, Hong Kong Special Administrative Region, China 出　　处：《Neural Regeneration Research》索引2008年第3卷第12期,共6页 基　　金：the Key Basic Research Developing Project of China (973 Project), No.2007CB947001;the State High Technology Development and Research Project of China (863 Project), No.2008AA02Z115;the Key Program of National Natural Science Foundation of China, No.30430240;Shanghai Metropolitan Fund for Research and Development, No. 04DZ14005,04JC14096 摘　　要：MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that they have profoundly important functions in brain development and pathological processes. For example, miR-124 plays an important role in inducing and maintaining neuronal identity through targeting at least two anti-neural factors. MicroRNAs have also been implicated in brain disorders, including brain tumors and neurodegenerative diseases. This review aims to present an overview of the expression profiles and functions of microRNAs in the developing brains of vertebrates. 关 键 词：神经形成 神经细胞 神经可塑性 转录调节剂 外成控制