Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal,healthy stomach

查看全文 作　　者：Katsunori [1]Iijima;Yasuhiko [1]Abe;Ryosuke [1]Kikuchi;Tomoyuki [1]Koike;Shuichi [1]Ohara;Pentti [2]Sipponen;Tooru [1]Shimosegawa

机构地区：[1]Division of Gastroenterology,Tohoku University Graduate School of Medicine;[2]Department of Pathology,Helsinki University Central Hospital,Jorvi Hospital

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第7期,共7页

摘　　要：AIM:To study the value of serum biomarker tests to differentiate between patients with healthy or diseased stomach mucosa:i.e.those with Helicobacter pylori(H pylori)gastritis or atrophic gastritis,who have a high risk of gastric cancer or peptic ulcer diseases.METHODS:Among 162 Japanese outpatients,pepsinogen-(Pg-)and(Pg)were measured using a conventional Japanese technique,and the European GastroPanel examination(Pg and Pg,gastrin-17 and H pylori antibodies).Gastroscopy with gastric biopsies was performed to classify the patients into those with healthy stomach mucosa,H pylori non-atrophic gastritis or atrophic gastritis.RESULTS:Pg-and Pg assays with the GastroPanel and the Japanese method showed a highly significant correlation.For methodological reasons,however,serum Pg-,but not Pg,was twice as high with the GastroPanel test as with the Japanese test.The biomarker assays revealed that 5%of subjects had advanced atrophic corpus gastritis which was also verified by endoscopic biopsies.GastroPanel examination revealed an additional seven patients who had either advanced atrophic gastritis limited to the antrum or antrum-predominant H pylori gastritis.When compared to the endoscopic biopsy findings,the GastroPanel examination classified the patients into groups with 'healthy' or 'diseased' stomach mucosa with 94% accuracy,95% sensitivity and 93% specifi city.CONCLUSION:Serum biomarker tests can be used to differentiate between subjects with healthy and diseased gastric mucosa with high accuracy. 关键词：血清标志物检测胃癌患者健康幽门螺杆菌胃炎消化性溃疡疾病萎缩性胃炎 HPYLORI 血清PG

相关文献

参考文献（40）
引证文献（28）
耦合文献（5）

参考文献(40)

引证文献(28)

耦合文献(5)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal,healthy stomach

参考文献(40)

引证文献(28)

耦合文献(5)

用户提示