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ANTI-INFLAMMATORY EFFECTS OF MAGNOLIAE FARGESII VOLATILE OIL

查看全文 作　　者：[1]王锋;[2]陈志东;[1]刑涛;[1]汪年松 高影响力作者 机构地区：[1]Department of Nephrology,Shanghai Sixth People's Hospital,Shanghai Jiaotong University;[2]Department of Pharmacy,Shanghai Sixth People's Hospital,Shanghai Jiaotong University高影响力机构 出　　处：《Journal of Shanghai Second Medical University(Foreign Language Edition)》索引2009年第21卷第1期,共5页高影响力期刊 摘　　要：Objective To explore the anti-inflammatory effects of magnoliae fargesii volatile oil.Methods Human umbilical vein endothelial cells (HUVECs) were stimulated by TNF-α to express the adhesion molecules. Then the anti-adhesion effects of magnoliae fargesii volatile oil between HUVECs and human peripheral neutrophils were observed. The ischemia-reperfusion animal models were established by 60min renal ischemia followed by 1, 3, 6 and 24h reperfusion. Rats were randomly divided into the following groups: the sham-operation controls, ischemic group only treated with normal saline, and treated group infused magnoliae fargesii volatile oil before reperfusion. Then the renal injury of rats was detected. Results High rate of cell adhesion between HUVECs and neutrophils was observed. Magnoliae fargesii volatile oil could inhibit the adhesion process at the concentration of 0.5μL/mL (191.6±8.6), 1.0μL/mL (158.2±9.0) and 2.0μL/mL (155.2±9.7) (P<0.05). The anti-adhesion effects were strengthened with the increase of volatile oil concentration. Blood urea nitrogen and creatinine levels of the animal models were significantly increased after 24h reperfusion while the increase was remarkably attenuated by the treatment with magnoliae fargesii volatile oil. The renal injury was severe after 1h reperfusion, which was significantly attenuated by the treatment of magnoliae fargesii volatile oil. Conclusion Magnoliae fargesii volatile oil has anti-inflammatory effects. 关 键 词：厚朴挥发油 抗炎作用 人脐静脉内皮细胞 外周血中性粒细胞 缺血再灌注 动物模型建立 注射生理盐水 HUVECS
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