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Isolation and characterization of xanthine oxidase inhibitory constituents of Pyrenacantha staudtii

查看全文 作  者:Abiodun [1]FALODUN;Muhammad Irfan [2]QADIR;Muhammad Iqbal [2]CHOULDARY 高影响力作者 机构地区:[1]Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria;[2]H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi 75270, Pakistan高影响力机构 出  处:《药学学报》索引2009年第44卷第4期,共5页高影响力期刊 摘  要:Six compounds have been isolated from the leaves of Pyrenacantha staudtii, two of which are new compounds. The new compounds have been characterized as kaempherol 3-O-β-rhamnopyranosyl (1→6)-β-D-glucopyranoside (1) and 4-β-glucopyranosyl-(2-furyl)-5-methy-l,2-glucopyranoside phenylmethanone (2). The known compounds are 3-pyridinecarboxylic acid (3), β-sitosterol (4), sitosterol 3-O-β-glucopyranoside (5) and taraxerol (6). Their structures were determined by spectroscopic and chemical evidences. The two new compounds together with 3-pyridinecarboxylic acid showed significant in vitro xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first report of these compounds from this plant. 关 键 词:化合物 药用植物 氧化酶 化学分析
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