Measurement of serum paraoxonase-1 activity in the evaluation of liver function

查看全文 作　　者：Jordi [1]Camps;Judit [1]Marsillach;Jorge [1]Joven

机构地区：[1]Centre of Biomedical Research,University Hospital Sant Joan,Institute of Health Research Pere Virgili,University Rovira i Virgili

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第16期,共5页

基　　金：Supported by Fondo de Investigación Sanitaria,FIS 00/0232,02/0430, 05/1607;the Instituto de Salud Carlos Ⅲ, C03/02,C03/08,G03/015;the Generalitat de Catalunya,FI 05/00068 摘　　要：Paraoxonase-1 (PON1) is an esterase and lactonase synthesized by the liver and found in the circulation associated with high-density lipoproteins. The physiological function of PON1 seems to be to degrade specific oxidized cholesteryl esters and oxidized phospholipids in lipoproteins and cell membranes. PON1 is, therefore, an antioxidant enzyme. Alterations in circulating PON1 levels have been reported in a variety of diseases involving oxidative stress including chronic liver diseases. Measurement of serum PON1 activity has been proposed as a potential test for the evaluation of liver function. However, this measurement is still restricted to research and has not been extensively applied in routine clinical chemistry laboratories. The reason for this restriction is due to the problem that the substrate commonly used for PON1 measurement, paraoxon, is toxic and unstable. The recent development of new assays with non-toxic substrates makes this proposal closer to a practical development. The present editorial summarizes PON1 biochemistry and function, its involvement with chronic liver impairment, and some aspects related to the measurement of PON1 activity in circulation. 关键词：肝功能活性酯酶血清检测临床化学实验室 PON1 高密度脂蛋白

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Measurement of serum paraoxonase-1 activity in the evaluation of liver function

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