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High level of ezrin expression in colorectal cancer tissues is closely related to tumor malignancy

查看全文 作　　者：Hong-Jian Wang Jin-Shui Zhu Qiang Zhang Qun Sun Hua [1]Guo 高影响力作者 机构地区：[1]Department of Gastroenterology, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2009年第15卷第16期,共4页高影响力期刊 基　　金：Supported by Natural Science Foundation of Shanghai,No.04ZB14072 摘　　要：AIM:To investigate the ezrin expression in normal colorectal mucosa and colorectal cancer tissues, and study the correlation between ezrin expression in colorectal cancer tissues and tumor invasion and metastasis.METHODS: Eighty paraffin-embedded cancer tissue samples were selected from primary colorectal adenocarcinoma. Twenty-eight patients had well-differentiated, 22 had moderately differentiated and 30 had poorly differentiated adenocarcinoma. Forty-five patients and 35 patients had lymph node metastasis. Forty-five patients were of Dukes A to B stage, and 35 were of C to D stage. Another 22 paraffi n-embedded tissue blocks of normal colorectal epithelium (>5 cm away from the edge of the tumor) were selected as the control group. All patients with colorectal cancer were treated surgically and diagnosed histologically, without preoperative chemotherapy or radiotherapy. The immunohistochemistry was used to detect the ezrin expression in paraffin-embedded normal colorectal mucosa tissues and colorectal cancer tissue samples.RESULTS: Ezrin expression in colorectal cancer was significantly higher than in normal colorectal mucosa (75.00% vs 9.09%, P<0.01), and there was a close relationship between ezrin expression and the degree of tumor differentiation, lymph node metastasis and Dukes stage (88.46% vs 50.00%, P<0.01; 94.28% vs 51.11%, P<0.01; 94.28% vs 51.11%, P<0.01).CONCLUSION: Ezrin expression is obviously higher in colorectal cancer tissues than in normal colorectal mucosa tissues, and the high level of ezrin expression is closely related to the colorectal cancer invasion and metastasis process. 关 键 词：肿瘤分化程度 大肠癌组织 恶性程度 石蜡包埋组织块 低分化腺癌 免疫组化法检测 DUKES分期 淋巴结转移
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