Review of salt consumption and stomach cancer risk:Epidemiological and biological evidence

查看全文 作　　者：Xiao-Qin [1]Wang;Paul D [2]Terry;Hong [1]Yan

机构地区：[1]Department of Epidemiology,School of Medicine, Xi'an Jiaotong University, Xi'an 710061,Shaanxi Province, China;[2]Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, United States

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第18期,共10页

摘　　要：Stomach cancer is still the fourth most common cancer;thus,it remains an important public health burden worldwide,especially in developing countries.The remarkable geographic variations in the rates of stomach cancer indicate that dietary factors,including a range of food groups to which salt and/or nitrates have been added,may affect stomach cancer risk.In this paper,we review the results from ecologic,case-control and cohort studies on the relationship between salt or salted foods and stomach cancer risk.The majority of ecological studies indicated that the average salt intake in each population was closely correlated with gastric cancer mortality.Most case-control studies showed similar results,indicating a moderate to high increase in risk for the highest level of salt or salted food consumption.The overall results from cohort studies are not totally consistent,but are suggestive of a moderate direct association.Since salt intake has been correlated with Helicobacter pylori(H pylori) infection,it is possible that these two factors may synergize to promote the development of stomach cancer.Additionally,salt may also cause stomach cancer through directly damaging gastric mucus,improving temporary epithelial proliferation and the incidence of endogenous mutations,and inducing hypergastrinemia that leads to eventual parietal cell loss and progression to gastric cancer.Based on the considerable evidence from ecological,case-control and cohort studies worldwide and the mechanistic plausibility,limitation on salt and salted food consumption is a practical strategy for preventing gastric cancer. 关键词：胃癌死亡率硝酸盐消费量流行病学证据病例对照研究食盐摄入量幽门螺杆菌

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Review of salt consumption and stomach cancer risk:Epidemiological and biological evidence

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耦合文献(265)

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