Red Yeast Rice Increases Excretion of Bile Acids in Hamsters

查看全文 作　　者：KA-YING [1]MA;ZE-SHENG [2]ZHANG;SHU-XIN [2]ZHAO;QI [3]CHANG;YIN-MEI [1]WONG;SAI YING VENUS [1]YEUNG;Yu [4]HUANG;AND ZHEN-YU [1]CHEN

机构地区：[1]Food and Nutritional Sciences Program, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China;[2]Faeulty of Food Engineering & Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China;[3]Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100193, China;[4]Department of Physiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

出　　处：《Biomedical and Environmental Sciences》索引2009年第22卷第4期,共9页

摘　　要：Objective To investigate the hypocholesterolemic activity of red yeast rice (RYR) and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR (0.1RYR) or 0.3% RYR (0.3RYR). Blood (0.5 mL) was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0, 3, and 6. Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. Results Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by 11% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, liver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7α-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K. It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 3-4 folds compared with the control value. Conclusion Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion. 关键词：HMGR HPLC 生物医学动物排泄物研究

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Red Yeast Rice Increases Excretion of Bile Acids in Hamsters

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