Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma

查看全文 作　　者：Rajko [1]Milosevic;Milena [1,2]Todorovic;Bela [3,4]Balint;Miodrag [3]Jevtic;Miodrag [1,2]Krstic;Elizabeta [3]Ristanovic;Nebojsa [1]Antonijevic;Mirjana [5]Pavlovic;Maja [1]Perunicic;Milan [1,2]Petrovic;Biljana [1,2]Mihaljevic

机构地区：[1]Clinical Center of Serbia,11000 Belgrade,Serbia;[2]Medical School,Belgrade University,11000 Belgrade,Serbia;[3]Military Medical Academy,11000 Belgrade,Serbia;[4]Institute for Medical Research,Belgrade University,11000 Belgrade,Serbia;[5]Charles Smith College of Science,FAU,33 431,Boca Raton,Fl,United States

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第32期,共7页

基　　金：Supported by Ministry of Science of Serbia,Project No.145061 摘　　要：AIM:To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS).METHODS: A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined. Splenectomy plus chemotherapy was applied in 20 patients, while splenectomy as a single treatment-option was performed in 10 patients. Prognostic factor and overall survival rate were analyzed.RESULTS: Complete remission (CR) was achieved in 20 (66.7%), partial remission (PR) in seven (23.3%), and lethal outcome due to disease progression occurred in three (10.0%) patients. Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank=0.056, P>0.05). Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions, as measured by computerized tomography and ultra-sound (t=2.558, P=0.018). Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank=5.244, P<0.05). The analysis of factors interfering with survival (by the Kaplan-Meier method) revealed that gender, general symptoms, clinical stage, and spleen infiltration type (nodular vs diffuse) had no significant (P>0.05) effects on the OS. The expression of other antigens (immunohistochemistry) also had no effect on survival-rate, as measured by a χ2 test (P>0.05).CONCLUSION: Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration; however, a larger controlled clinical study is required to conf irm our findings. 关键词：淋巴瘤边缘带治疗化疗手术脾

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Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma

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