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Capecitabine treatment patterns in patients with gastroesophageal cancer in the United States

查看全文 作　　者：Muhammad Wasif [1]Saif;Nianwen [2]Shi;Susan [3]Zelt 高影响力作者 机构地区：[1]Gastrointestinal Cancers Program, Yale Medical Oncology,New Haven,CT 06519,United States;[2]Thomson Reuters,Cambridge,MA 02140, United States;[3]Medical Data Management and Analytics,Roche, Nutley,NJ 07110,United States高影响力机构 出　　处：《World Journal of Gastroenterology》索引2009年第15卷第35期,共8页高影响力期刊 基　　金：Supported by Roche 摘　　要：AIM:To assess the use of capecitabine-based therapy and associated complication rates in patients with gastroesophageal cancer(GEC)in a real-world treatment setting. METHODS:Patients with claims between 2004 and 2005 were identified from the Thomson Reuters MarketScan  databases.Capecitabine regimens were compared with 5-fluorouracil(5-FU)and other chemotherapy regimens,and were stratified by treatment setting. RESULTS:We identified 1013 patients with GEC:approximately half had treatment initiated with a 5-FU regimen,whereas 11%had therapy initiated with a capecitabine regimen.The mean capecitabine dose overall was 2382±1118 mg/d,and capecitabine was used as monotherapy more often than in combination. Overall,5-FU regimens were the most common treatment option in neoadjuvant and adjuvant settings, while other non-capecitabine regimens were used more widely in first-and second-line settings.The overall unadjusted complication rate for capecitabine regimens was about half of that seen with 5-FU regimens.In multivariate analyses,capecitabine recipients had a 51%(95%CI:26%-81%)lower risk of developing any complication than 5-FU recipients did.The risk of developing bone marrow,constitutional,gastrointestinal tract,infectious,or skin complications was lowerwith capecitabine therapy than with 5-FU.CONCLUSION:Capecitabine appeared to have a favorable side effect profile compared with 5-FU,which indicates that it may be a treatment option for GEC. 关 键 词：治疗方案 胃肠道 患者 癌症 分层设置 美国 精神疾病 氟尿嘧啶
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