Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver

查看全文 作　　者：Takayuki [1,2,3]Takeichi;Shinji [1]Uemoto;Sachiko [4]Minamiguchi;Izumi [2]Takeyoshi;Yukihiro [3]Inomata;Koichi [1]Tanaka;Eiji [5]Kobayashi

机构地区：[1]Department of Transplantation and Immunology, Kyoto University Hospital, 54 Kawara-cho, Shogoin,Sakyo-ku, Kyoto 606-8507, Japan;[2]Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan;[3]Department of Trans-plantation and Pediatric Surgery, Postgraduate School of Medical Science, Kumamoto University, Kumamoto, 1-1-1 Honjyo, Ku-mamoto 860-8556, Japan;[4]Laboratory of Anatomic Pathology, Kyoto University Hospital, 54 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;[5]Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Minami-kawachi-machi, Kawachi-gun, Tochigi 329-0498, Japan

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第45期,共4页

摘　　要：AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury. 关键词：再灌注损伤缺血再灌注肝损伤大鼠模型受体拮抗剂谷草转氨酶联合生产加性效应

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Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver

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