Peutz-Jeghers syndrome:Diagnostic and therapeutic approach

查看全文 作　　者：Marcela [1]Kopacova;Ilja [1]Tacheci;Stanislav [1]Rejchrt;Jan [1]Bures

机构地区：[1]2nd Department of Medicine,Charles University in Praha,Faculty of Medicine at Hradec Králové,University Teaching Hospital,Sokolská581,Hradec Králové500 05, Czech Republic

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第43期,共12页

基　　金：Supported by Research Project MZO 00179906 From theMinistry of Health,Czech Republic 摘　　要：Peutz-Jeghers syndrome(PJS)is an inherited,autosomal dominant disorder distinguished by hamartomatous polyps in the gastrointestinal tract and pigmented mucocutaneous lesions.Prevalence of PJS is estimated from 1 in 8300 to 1 in 280 000 individuals.PJS predisposes sufferers to various malignancies(gastrointestinal,pancreatic,lung,breast,uterine,ovarian and testicular tumors).Bleeding,obstruction and intussusception are common complications in patients with PJS.Double balloon enteroscopy(DBE)allows examination and treatment of the small bowel.Polypectomy using DBE may obviate the need for repeated urgent operations and small bowel resection that leads to short bowel syndrome.Prophylaxis and polypectomy of the entire small bowel is the gold standard in PJS patients.Intraoperative enteroscopy(IOE)was the only possibility for endoscopic treatment of patients with PJS before the DBE era.Both DBE and IOE facilitate exploration and treatment of the small intestine. DBE is less invasive and more convenient for the pa- tient.Both procedures are generally safe and useful. An overall recommendation for PJS patients includes not only gastrointestinal multiple polyp resolution,but also regular lifelong cancer screening(colonoscopy, upper endoscopy,computed tomography,magnetic resonance imaging or ultrasound of the pancreas, chest X-ray,mammography and pelvic examinationwith ultrasound in women,and testicular examination in men).Although the incidence of PJS is low,it is important for clinicians to recognize these disorders to prevent morbidity and mortality in these patients,and to perform presymptomatic testing in the first-degree relatives of PJS patients. 关键词：综合征治疗诊断黑斑肉

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Peutz-Jeghers syndrome:Diagnostic and therapeutic approach

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