白细胞介素-18抑制Lewis肺癌小鼠移植瘤生长与诱导移植瘤细胞凋亡的研究(英文)

查看全文 作　　者：Sheng [1]Yang;Huishan [1]Lu;Xiangqi [2]Chen;Tingyan [2]Lin;Zhiying [2]Li;Mingqiang [3]Kang

机构地区：[1]Department of Oncology, the Union Hospital of Fujian Medical University, Fuzhou 350001, China;[2]Department of Respiration, the UniOn Hospital of Fujian Medical University, Fuzhou 350001, China;[3]Department of Thoracic Surgery, the Union Hospital of Fujian Medical University, Fuzhou 350001, China

出　　处：《The Chinese-German Journal of Clinical Oncology》索引2010年第9卷第3期,共3页

基　　金：Supported by the grants of the Natural Science Foundation Program of Fujian Province (No. 2006J0342);the Scholastic Development Foundation of Fujian Medical University (No. JS07006) 摘　　要：Objective:The aim of our study was to investigate the effects of interleukin-18(IL-18) on implanted Lewis lung cancer in suppressing tumor growth and inducing tumor cells apoptosis.Methods:One week after hypodermic inoculation of Lewis cells, sixteen tumor-bearing syngeneic mice were randomly divided into two groups.The mice in the treatment group were intraperitoneal injected with the IL-18, in the control group were intraperitoneal injected with normal saline.The health conditions of the mice were measured, the morphology of the tumors was studied and the apoptosis of implanted lung cancer cells was detected by TUNEL to evaluated the effects of IL-18.Results:IL-18 had no significant effects on the health conditions of the mice, but it could suppress the implanted tumor growth(inhibition rate was 75%) and induce tumor cells apoptosis.Conclusion:IL-18 can suppress the implanted Lewis lung cancer cells by way of inducing tumor cells apoptosis.It could be used as a new strategy for lung cancer. 关键词：白细胞介素-18 肿瘤细胞凋亡肺癌细胞凋亡诱导肿瘤生长抑制肿瘤移植荷瘤小鼠

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白细胞介素-18抑制Lewis肺癌小鼠移植瘤生长与诱导移植瘤细胞凋亡的研究(英文)

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