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Relationships between serum lipid,lipoprotein,triglyceride-rich lipoprotein,and high-density lipoprotein particle concentrations in post-renal transplant patients

查看全文 作　　者：ElZbieta [1]KIMAK;Magdalena [1]HALABI;Iwona BARANOWICZ-[2]GASZCZYK 高影响力作者 机构地区：[1]Department of Laboratory Diagnostics,Medical University of Lublin,ul. Chod■ki 1,20-093 Lublin,Poland;[2]Department of Nephrology,Medical University of Lublin,Jaczewskiego 8,20-093 Lublin,Poland高影响力机构 出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》索引2010年第11卷第4期,共9页高影响力期刊 基　　金：Project (Nos. PW 55/09 and DS 41/09) supported by the Department of Laboratory Diagnostics, Medical University of Lublin, Poland 摘　　要：Objective:Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. Methods:Serum levels of lipids,lipoprotein,triglyceride-rich lipoproteins (TRLs),and high-density lipoprotein (HDL) particles were determined,lipid and lipoprotein ratios were calculated,and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx patients and 89 healthy subjects. HDL particle levels were de-termined by enzyme-linked immunosorbent assay (ELISA). Results:Tx patients had disturbed concentration,com-position,and metabolism of TRLs and HDL particles. Multivariance analysis showed significant and positive correlation between HDL cholesterol/apoAI (HDL-C/apoAI) and HDL-C/HDL ratios,which indicates that both ratios could sensi-tively reflect changes in the HDL subclasses and their distribution into smaller size particles. In Tx patients,the de-creased HDL-C/apoAI ratio indicates that,along with the decreased apoAI concentration,the HDL-C level is de-creased. However,a low HDL-C/HDL ratio indicates that HDL particles in Tx patients transport lesser content of HDL-C but more triglyceride (TG) (high TG/HDL ratio),and thus are hypercatabolized and removed; therefore,con-centration of HDL particles in serum was decreased. Conclusion:The decrease of HDL-C/apoAI ratio seems to be a good marker of HDL subclass distribution into smaller size particles. 关 键 词：LIPID LIPOPROTEIN High-density lipoprotein particle Triglyceride-rich lipoprotein Renal transplantation
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