Prevalence of Anti-endothelial Cell Antibodies in Patients with Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases

查看全文 作　　者：Meng-tao [1]Li;Jun [1]Ai;Zhuang [2]Tian;Quan [2]Fang;Wen-jie [1]Zheng;Xue-jun [1]Zeng;Xiao-feng [1]Zeng

机构地区：[1]Department of Rheumatology,;[2]Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

出　　处：《Chinese Medical Sciences Journal》索引2010年第25卷第1期,共5页

基　　金：Supported by Chinese National Key Technology R&D Program (2006BAI01A07, 2008BAI59B02);Clinical Grant of Chinese Medicine Association (08010270105) 摘　　要：Objective To investigate the prevalence of anti-endothelial cell antibodies (AECAs) in the sera of connective tissue diseases (CTD) patients with pulmonary arterial hypertension (PAH) and its correlation with clinical manifestations. Methods AECAs in sera of 39 CTD patients with PAH,22 CTD patients without PAH,and 10 healthy donors as controls were detected with Western blotting. The prevalence of different AECAs in different groups was compared and its correlation with clinical manifestations was also investigated. Results The prevalence of AECAs was 82.1% in CTD patients with PAH,72.7% in CTD patients without PAH,and 20.0% in healthy donors. Anti-22 kD AECA was only detected in CTD patients with PAH (15.4%). Anti-75 kD AECA was more frequently detected in CTD patients with PAH than in those without PAH (51.3% vs. 22.7%,P<0.05). In CTD patients with PAH,anti-75 kD AECA was more frequently detected in those with Raynaud’s phenomenon or with positive anti-RNP antibody. Conclusion AECAs could be frequently detected in CTD patients with or without PAH,while anti-22 kD and anti-75 kD AECA might be specific in CTD patients with PAH. 关键词：结缔组织肺动脉高压内皮细胞患者抗体多环芳烃临床表现 PAH

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Prevalence of Anti-endothelial Cell Antibodies in Patients with Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases

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