大肠癌中Livin和IGF-Ⅱ表达的相关性研究(英文)

查看全文 作　　者：Guanming Bao Changwu Zhang Gexin [1]Wang

机构地区：[1]Department of Oncology, The People's Hospital of Tongcheng, Tongcheng 231400, China

出　　处：《The Chinese-German Journal of Clinical Oncology》索引2010年第9卷第8期,共5页

摘　　要：Objective:The aim of the study was to test the expressions of Livin and insulin-like growth factor Ⅱ(IGF-Ⅱ) in colorectal cancers and discuss their significance of carcinogenesis and progression in colorectal cancers,to provide a new target and theory basement for cancer therapy.Methods:The expressions of Livin and IGF-Ⅱ were detected by immunohistochemistry SABC in 60 cases of colorectal cancer and their associated colorectal tissues,and the associations between the expression levels of Livin and IGF-Ⅱ and clinical pathological characteristics were analyzed.Results:The positive rates of Livin and IGF-Ⅱ in colorectal carcinomas were 68.33% and 63.33% respectively,higher than those of para-carcinomatous normal tissues and colorectal adenomas.There were no significant correlations between the expressions of Livin,IGF-Ⅱ in colorectal carcinomas and the patient's age,sex,tumor size and location,while distant metastasis,Dukes stage,histological type,lymph node metastasis,and whether the tumors have received radiotherapy and chemotherapy were significantly correlated with the expressions of Livin,IGF-Ⅱ in colorectal carcinomas.Conclusion:Livin and IGF-Ⅱ play important roles in carcinogenesis and progression of colorectal cancer.This study showed obvious correlation between the expressions of Livin and IGF-Ⅱ in colorectal cancers.It could be used as the reference for further researches.Livin is hopeful to be a new molecular target in cancer therapy. 关键词：LIVIN 大肠癌 IGF 胰岛素样生长因子免疫组织化学癌症治疗 SABC法结直肠癌

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大肠癌中Livin和IGF-Ⅱ表达的相关性研究(英文)

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