Clonal Characterization of Bone Marrow Derived Stem Cells and Their Application for Bone Regeneration

查看全文 作　　者：Shobha [1]Mareddy;Ross [1]Crawford

机构地区：[1]Institute of Health and Biomedical Innovation,Queensland University of Technology

出　　处：《International Journal of Oral Science》索引2010年第2卷第3期,共9页

摘　　要：Tissue engineering allows the design of functionally active cells within supportive bio-scaffolds to promote the development of new tissues such as cartilage and bone for the restoration of pathologically altered tissues.However,all bone tissue engineering applications are limited by a shortage of stem cells.The adult bone marrow stroma contains a subset of nonhematopoietic cells referred to as bone marrow mesenchymal stem cells(BMSCs).BMSCs are of interest because they are easily isolated from a small aspirate of bone marrow and readily generate single-cell-derived colonies.These cells have the capacity to undergo extensive replication in an undifferentiated state ex vivo.In addition,BMSCs have the potential to develop either in vitro or in vivo into distinct mesenchymal tissues,including bone,cartilage,fat,tendon,muscle,and marrow stroma.Thus,BMSCs are an attractive cell source for tissue engineering approaches.However,BMSCs are not homo-geneous and the quantity of stem cells decreases in the bone marrow in aged population.A sequential loss of lineage differentiation potential has been found in the mixed culture of bone marrow stromal cells due to a heterogenous popu-lation.Therefore,a number of studies have proposed that homogenous bone marrow stem cells can be generated from clonal culture of bone marrow cells and that BMSC clones have the greatest potential for the application of bone regeneration in vivo. 关键词：骨髓干细胞骨髓基质干细胞克隆鉴定再生骨组织工程骨髓基质细胞骨髓间质干细胞分化潜能

相关文献

参考文献（41）
引证文献（15）
耦合文献（0）

参考文献(41)

引证文献(15)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Clonal Characterization of Bone Marrow Derived Stem Cells and Their Application for Bone Regeneration

参考文献(41)

引证文献(15)

用户提示