An Association between Immunosenescence and CD4^+CD25^+ Regulatory T Cells: A Systematic Review

查看全文 作　　者：LING WANG YAN XIE LI-JING ZHU TING-TING CHANG YAN-QING MAO JIE [1]LI

机构地区：[1]Clinical Immunology Laboratory, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China

出　　处：《Biomedical and Environmental Sciences》索引2010年第23卷第4期,共6页

基　　金：supported by the National Natural Science Foundation of China (No.30330540);the Jiangsu Provincial Fund for Clinical Immunology Key Laboratory (No.200319);the Scientific and Technological Fund to Support Project of Suzhou City (ZS0901) 摘　　要：Objective Age-related increment of the prevalence of CD4+CD25+ regulatory T (Treg) cells were described controversially, and whether such changes explain immune dysfunction in the elderly is still unclear. The aim of this systematic review is to evaluate the role of the Tregs in immunosenescence. Methods Medline and manual searches were performed to identify all published epidemiological and animal studies investigating the efficacy of the association between immunosenescence and Treg cells. Results It was founded that the frequency, phenotypic characteristics, and number/function of Tregs were altered significantly with aging. Medical conditions in individuals with advanced ageas well as apoptosis intensity of Treg cells had an impact on the accumulation of Tregs which in turn could deteriorate cytotoxic activity of CD8+ T and NK cells and production of IL-2. The range of immune cells that could be suppressed by Treg cells was quite wide and covered CD4+CD25+ T cells, NK cells, dendritic cells and even monocytes. These changes were observed both in humans and experimental animals. Besides, it was believed that frequency of Tregs increased with age and was accompanied by intensified suppressive activity for Tregs in patients, for example, with Alzheimer disease (AD) and Parkinson disease (PD). The impaired condition of CD4+ T cells, so-called immunosenescence, rendered transplant recipients less responsive to an allogeneic kidney graft, an effect that was limited to transplant recipients who were aged over 60 years. Conclusions Treg cells are associated with immunosenescence. All these changes contribute to the aging-related decline of immune responses and lead to the higher risk of immune-mediated diseases, cancer or infections in aged individuals. 关键词：调节性T细胞免疫细胞 CD4 衰老协会系统 EG细胞阿尔茨海默病

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An Association between Immunosenescence and CD4^+CD25^+ Regulatory T Cells: A Systematic Review

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