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Muscarinic receptor-mediated calcium changes in a rat model of facial nerve nucleus injury

查看全文 作　　者：Dawei [1]Sun;Huamin [2]Liu;Fugao [1]Zhu;Yanqing [3]Wang;Junfeng [1]Wen;Rui [4]Zhou;Yanjun [5]Wang;Banghua [5]Liu 高影响力作者 机构地区：[1]Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China;[2]Department of Oncology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China;[3]Department of Science and Education, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province China;[4]School of Public Health, Shandong University, Jinan 250012, Shandong Province, China;[5]Department of Otolaryngology-Head and Neck Surgery, Union Hospital of Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2010年第5卷第18期,共5页高影响力期刊 基　　金：Youth Scientific Research Foundation of Qingdao University (2007) 摘　　要：The muscarinic receptor modulates intracellular free calcium ion levels in the facial nerve nucleus via different channels.In the present study,muscarinic receptor-mediated free calcium ions levels were detected by confocal laser microscopy in the facial nerve nucleus following facial nerve injury in rats.There was no significant difference in muscarinic receptor expression at the affected facial nerve nucleus compared with expression prior to injury,but muscarinic receptor-mediated free calcium ion levels increased in the affected side following facial nerve injury (P < 0.01).At day 30 after facial nerve injury,50 μmol/L muscarinic-mediated free calcium ion levels were significantly inhibited at the affected facial nerve nucleus in calcium-free artificial cerebrospinal fluid,and the change range was 82% of artificial cerebrospinal fluid (P < 0.05).These results suggest that increased free calcium ion concentrations are achieved by intracellular calcium ion release,and that the transmembrane flow of calcium ions is also involved in this process. 关 键 词：细胞内游离钙 毒蕈碱受体 面神经核 受体介导 神经损伤 大鼠 面部 激光共聚焦显微镜
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