Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na^+ neuronal current

查看全文 作　　者：Jingyan [1]Ge;Yinan [2]Wang;Haiyan [3]Liu;Fangfang [2]Chen;Xueling [4]Cui;Zhonghui [2]Liu

机构地区：[1]Department of Physiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China;[2]Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China;[3]Department of Anatomy, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China;[4]Department of Genetics, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China

出　　处：《Neural Regeneration Research》索引2010年第5卷第19期,共6页

基　　金：the National Natural Science Foundation of China, No.30903123, 30901329;the Project of Science and Technology of Jilin Province, No.20090741, 20090185 摘　　要：Activin A,which was first described in 1986,has been shown to maintain hippocampal neuronal survival.Activin A increases intracellular free Ca2+ via L-type Ca2+ channels.Our previous study showed that activin A promotes neurite growth of dorsal root ganglia in embryonic chickens and inhibits nitric oxide secretion.The present study demonstrated for the first time that activin A could maintain cerebral cortex neuronal survival in vitro for a long period,and that activin A was shown to increase voltage-gated Na+ current(INa) in Neuro-2a cells,which was recorded by patch clamp technique.The present study revealed a novel mechanism for activin A,as well as the influence of activin A on neurons by regulating expressions of vasoactive intestine peptide and inducible nitric oxide synthase. 关键词：海马神经细胞大脑皮层激活素电压门控钠电流 Na 一氧化氮合成酶维护

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Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na^+ neuronal current

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