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Nicotine alpha 4 beta 2 receptor-mediated free calcium in an animal model of facial nucleus injury

查看全文 作　　者：Dawei [1]Sun;Wenhai [1]Sun;Yanqing [2]Wang;Fugao [1]Zhu;Rui [3]Zhou;Yanjun [4]Wang;Banghua [4]Liu;Xiuming [1]Wan;Huamin [5]Liu 高影响力作者 机构地区：[1]Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China;[2]Department of Science and Education, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China;[3]School of Public Health, Shandong University, Jinan 250012, Shandong Province, China;[4]Department of Otolaryngology Head and Neck Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China;[5]Department of Oncology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2010年第5卷第19期,共5页高影响力期刊 基　　金：Youth Research Fund of Qingdao University (2007) 摘　　要：Previous studies have demonstrated that the cholinergic system,via nicotinic receptors,regulates intracellular free calcium levels in the facial nucleus under normal physiological conditions.However,the regulation of nicotinic receptors on free calcium levels following facial nerve injury remains unclear.In the present study,an animal model of facial nerve injury was established,and changes in nicotinic receptor expression following facial nerve injury in rats were detected using reverse transcription polymerase chain reaction.Nicotinic receptor-mediated changes of free calcium levels following facial nucleus injury were determined by laser confocal microscopy.Results showed no significant difference in nicotinic receptor expression between the normal group and the affected facial nerve nucleus.The nicotinic receptor α4β2 subtype increased free calcium levels following facial nerve injury by promoting calcium transmembrane influx,and L-type voltage-gated calcium channel-mediated influx of calcium ions played an important role in promoting calcium transmembrane influx.The nicotinic receptor-mediated increase of free calcium levels following facial nerve injury provides an important mechanism for the repair of facial nerve injury. 关 键 词：神经损伤修复 受体介导 动物模型 细胞内游离钙 阿尔法 逆转录聚合酶链反应 激光共聚焦显微镜 烟碱受体
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