Increased stromal-cell-derived factor 1 enhances the homing of bone marrow derived mesenchymal stem cells in dilated cardiomyopathy in rats

查看全文 作　　者：ZHOU Yan-[1,2]li;ZHANG Hai-[1]feng;LI Xin-[1]li;DI Ruo-[1]min;YAO Wen-[1]ming;LI Dian-[1,2]fu;FENG Jian-[2]lin;HUANG [1]Jun;CAO Ke-[1]jiang;Michael [3]Fu

机构地区：[1]Department of Cardiology , First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, Nanjing, Jiangsu 210029, China;[2]Department of Nuclear Medicine , First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital, Nanjing, Jiangsu 210029, China;[3]Depatrtment of Medicine/Wallenberg Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden

出　　处：《Chinese Medical Journal》索引2010年第22期,共6页

基　　金：This study was supported by the National Natural Science Foundation of China (No. 30900603), Specialized Research Fund for the Doctoral Program of Higher Education (No. 20093234110008 and No. 20093234120008), and Project Supported by Department of Health of Jiangsu Province (No. ZX07 200902) 摘　　要：背景干细胞移植被显示了在扩大心肌症上有有益的效果。然而,为到在扩大心肌症的心脏的织物的干细胞 homing 的机制还没是 elucidated.Methods 间充质的干细胞从老鼠骨头髓被获得,在 vitro 膨胀了,并且用 99mTc 标记 .Cardiomyopathy 模特儿被 doxorubicin 在老鼠劝诱。标记房间的 99mTc 在心肌症和控制老鼠被灌输进左室。在注射以后的十六个小时,动物被牺牲,不同纸巾被收获测量特定的放射性。由即时聚合酶链反应和 immunohistochemistry 的使用,为在心脏的织物的 stromal-cell-derived 因素 1 的 Mrna 和蛋白质表情是把间充质的干细胞的效率标记的 measured.Results (70. 关键词：基质细胞衍生因子间质干细胞心肌病大鼠归巢骨髓干细胞移植免疫组织化学

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Increased stromal-cell-derived factor 1 enhances the homing of bone marrow derived mesenchymal stem cells in dilated cardiomyopathy in rats

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