Effect of Matricaria chamomilla Hydroalcoholic Extract on Cisplatin-induced Neuropathy in Mice

查看全文 作　　者：A. Namvaran Abbas [1]Abad;M.H. Kayate [2]Nouri;A. [3]Gharjanie;F. [4]Tavakoli

机构地区：[1]Graduated from Veterinary Medicine, Islamic Azad University;[2]Department of Pharmacology, Faculty of Veterinary Medicine, Islamic Azad University Tabriz Branch;[3]Department of Pharmacology, Tabriz University of Medical Science;[4]Graduated from Food Science Engineering, Islamic Azad University

出　　处：《中国天然药物》索引2011年第9卷第2期,共6页

摘　　要：AIM: Cisplatin-based chemotherapy is a mainstay for the treatment of solid tumors, especially colorectal, ovarian, testicular, bladder, and lung cancer. Studies have shown that cisplatin could have painful effects on human and animal models. Matri-caria chamomilla (MC) has analgesic and anti-inflammatory effects. The aim of this study was to investigate the effects of MC hydro-alcoholic extract on cisplatin-induced peripheral neuropathy and to compare with morphine in mice. METHODS: Experiments were performed on 60 NMRI male mice weighed 25 g to 30 g which have been divided into 6 groups. The first group received normal saline; the second group received MC hydroalcoholic extract; the third group received cisplatin; the fourth group received MC hydroalcoholic extract and cisplatin, 96 hours before formalin test; the fifth group received morphine and the sixth group received cisplatin and mor-phine. The time of injected hind paw biting and licking time were measured in 5-minute interval for an hour. RESULTS: Results showed that formalin induced significant (P < 0.05) pain response (the first phase: 0-5 min and the second phase: 15-40 min after injection). Administration of MC extract before formalin injection showed significant (P < 0.05) decrease of pain responses in the first and second phase. Administration of cisplatin produced significant (P < 0.05) increase in pain response in both phases of formalin test. Injection of MC extract and cisplatin together have shown that MC is able to decrease the second phase of cisplatin-induced pain sig-nificantly (P < 0.05). Morphine decreased cisplatin-induced pain in the first and second phase of formalin test significantly ( P < 0.05). In comparison morphine has analgesic effects in the first phase and MC extract has anti inflammatory effects in the second phase of formalin test significantly (P < 0.05). CONCLUSION: MC and cisplatin have analgesic and painful neuropathic respective effects, and MC hydroalcoholic extract is able to decrease cisplatin-induced pain and inflammation better than morphine. 关键词：Matricaria chamomilla CISPLATIN PAIN MICE

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Effect of Matricaria chamomilla Hydroalcoholic Extract on Cisplatin-induced Neuropathy in Mice

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