Effects of cotransplantated Schwann cells and neural stem cells in a rat model of Alzheimer's disease

查看全文 作　　者：Yan [1,2]Zhan;Dihui [2]Ma;Yu [2]Zhang

机构地区：[1]Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China;[2]Department of Neurology, First Clinical Hospital of Jilin University, Changchun 130021, Jilin Province, China

出　　处：《Neural Regeneration Research》索引2011年第6卷第4期,共7页

基　　金：the Science and Technology Development Foundation of Jilin Province, No. 200505204, 200705129 摘　　要：Schwann cells (SCs) are significantly better at promoting neural stem cell (NSCs) proliferation, differentiation and synaptic formation when cocultured with NSCs in vitro, compared with cultured in a single nerve growth factor. The present study transplanted NSCs and SCs into the brain of a rat model of Alzheimer's disease to investigate the effect of cotransplantation. Results show transplantation of both NSCs alone and NSCs + SCs significantly promoted learning and memory functions in Alzheimer's disease rats, decreased glial fibrillary acidic protein and calcium binding protein S100β expression, but increased expression of the cholinergic neuron marker choline acetyl transferase mRNA. The effect of NSCs + SCs cotransplantation was, however, more significant. NSCs and SCs cotransplantation significantly reduced the number of astrocytes and increased cholinergic neurons, facilitating the recovery of learning and memory function, compared with NSCs transplantation alone. 关键词：神经干细胞移植阿尔茨海默病雪旺氏细胞大鼠模型胶质纤维酸性蛋白胆碱能神经元阿尔茨海默氏病胆碱乙酰转移酶

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Effects of cotransplantated Schwann cells and neural stem cells in a rat model of Alzheimer's disease

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