Multifaceted nature of membrane microdomains in colorectal cancer

查看全文 作　　者：Kristina A [1]Jahn;Filip [1]Braet

机构地区：[1]Australian Centre for Microscopy and Microanalysis,The University of Sydney

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第6期,共10页

基　　金：Supported by The Australian Research Council through Linkage Infrastructure, Equipment and Facilities grants, No.LE0775598;the ARC/NHMRC FABLS Research Network, No.RN0460002 摘　　要：Membrane microdomains or lipid rafts are known to be highly dynamic and to act as selective signal transduction mediators that facilitate interactions between the cell's external and internal environments.Lipid rafts play an important mediating role in the biology of cancer:they have been found in almost all existing experimental cancer models,including colorectal cancer (CRC),and play key regulatory roles in cell migration,metastasis,cell survival and tumor progression.This paper explores the current state of knowledge in this field by highlighting some of the pioneering and recent lipid raft studies performed on different CRC cell lines and human tissue samples.From this literature review,it becomes clear that membrane microdomains appear to be implicated in all key intracellular signaling pathways for lipid metabolism,drug resistance,cell adhesion,cell death,cell proliferation and many other processes in CRC.All signal transduction pathways seem to originate directly from those peculiar lipid islands,thereby orchestrating the colon cancer cells' state and fate.As confirmed by recent animal and preclinical studies in different CRC models,continuing to unravel the structure and function of lipid rafts-including their associated complex signaling pathways-will likely bring us one step closer to better monitoring and treating of colon cancer patients. 关键词：微区大肠癌膜信号转导通路信号传导细胞迁移 RC模型脂质筏

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Multifaceted nature of membrane microdomains in colorectal cancer

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