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HBV infection decreases risk of liver metastasis in patients with colorectal cancer:A cohort study

查看全文 作　　者：Hai-Bo [1,2,3]Qiu;Zhao-Lei [1,5]Zeng;Zhi-Qiang [1,2]Wang;Hui-Yan [1,2]Luo;Rajiv Prasad [1,2]Keshari;Zhi-Wei [1,3]Zhou;Rui-Hua [1]Xu;Li-Yi [4]Zhang 高影响力作者 机构地区：[1]State Key Laboratory of Oncology in South China, Guangzhou 510060, Guangdong Province, China;[2]Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China;[3]Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China;[4]Department of Clinical Oncology, University of HongKong, Pokfulam, HongKong, China;[5]Department of Research, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2011年第17卷第6期,共5页高影响力期刊 基　　金：Supported by National Natural Science Foundation of China,No.30672408 摘　　要：AIM:To evaluate the effect of hepatitis B virus (HBV) infection on liver metastasis of colorectal cancer.METHODS:A total of 1298 colorectal cancer patients were recruited from January 2001 to March 2005 in this study.Enzyme-linked immunosorbent assay was used to test serum HBV markers for colorectal cancer.Patients were divided into study (infection) group and control (non-infection) group.Clinical features of patients in two groups were compared.RESULTS:Liver metastasis was found in 319 out of the 1298 colorectal cancer patients.The incidence of liver metastasis was significantly lower in study group than in control group (14.2% vs 28.2%,P < 0.01).HBV infection significantly decreased the risk of liver metastasis [hazard ratio (HR):0.50,95% confidence interval (95% CI):0.38-0.66],but the incidence of extrahepatic metastasis was significantly higher in study group than in control group (31.9% vs 17.0%,P < 0.01).The HR was the lowest in chronic hepatitis B group (HR:0.29,95% CI:0.12-0.72).The number of liver metastatic lesions was significantly less in study group than in control group with a higher surgical resection rate.However,no significant difference was found in survival rate between the two groups (P=0.95).CONCLUSION:HBV infection decreases the risk of liver metastasis in patients with colorectal cancer and elevates the surgical resection rate of liver metastatic lesions. 关 键 词：乙肝病毒 大肠癌 HBV 患者 感染 队列研究 风险 酶联免疫吸附试验
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