Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010

查看全文 作　　者：Chakshu [1]Sharma;Karim M [1]Eltawil;Paul D [1]Renfrew;Mark J [1]Walsh;Michele [1]Molinari

机构地区：[1]Department of Surgery, Queen Eliz-abeth Ⅱ Health Sciences Center, Dalhousie University

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第7期,共31页

摘　　要：Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic. 关键词：辅助治疗诊断方法胰腺癌手术切除生存时间临床试验标记鉴定遗传学

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Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010

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