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Intraductal papillary neoplasm of the bile duct in liver cirrhosis with hepatocellular carcinoma

查看全文 作　　者：Jing [1,2]Xu;Yasunori [1]Sato;Kenichi [1]Harada;Norihide [1]Yoneda;Yasuni [1]Nakanuma;Teruyuki [3]Ueda;Atsushi [4]Kawashima;Akishi [4]Ooi 高影响力作者 机构地区：[1]Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan;[2]Department of Pathology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China;[3]Internal Medicine for Digestive Organs, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan;[4]Department of Molecular Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan高影响力机构 出　　处：《World Journal of Gastroenterology》索引2011年第17卷第14期,共4页高影响力期刊 摘　　要：A case of intraductal papillary neoplasm of the bile duct (IPNB) arising in a patient with hepatitis B-related liver cirrhosis with hepatocellular carcinoma (HCC) is reported. A 76-year-old man was admitted to our hospital with recurrent HCC. Laboratory data showed that levels of carcinoembryonic antigen and carbohydrate antigen 19-9 were elevated. He died of progressive hepatic failure. At autopsy,in addition to HCCs,an intraductal papillary proliferation of malignant cholangiocytes with fibrovascular cores was found in the dilated large bile ducts in the left lobe,and this papillary carcinoma was associated with an invasive mucinous carcinoma (invasive IPNB). Interestingly,extensive intraductal spread of the cholangiocarcinoma was found from the reactive bile ductular level to the interlobular bile ducts and septal bile ducts and to the large bile ducts in the left lobe. Neural cell adhesion molecule,a hepatic progenitor cell marker,was detected in IPNB cells. It seems possible in this case that hepatic progenitor cells located in reactive bile ductules in liver cirrhosis may have been responsible for the development of the cholangiocarcinoma and HCC,and that the former could have spread in the intrahepatic bile ducts and eventually formed grossly visible IPNB. 关 键 词：肝硬化 胆管 肝癌 乳头 管内 肿瘤 神经细胞粘附分子 癌胚抗原
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