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Dl-3-butylphthalide-enhanced hematopoietic stem cell transplantation and endogenous stem cell mobilization for the treatment of cerebral infarcts

查看全文 作　　者：Baoquan [1]Lu;Xiaoming [2]Shang;Yongqiu [1]Li;Hongying [1]Ma;Chunqin [1]Liu;Jianmin [3]Li;Yingqi [4]Zhang;Shaoxin [5]Yao 高影响力作者 机构地区：[1]Department of Neurology, Tangshan Workers' Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China;[2]Department of Cardiology, Tangshan Workers' Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China;[3]Department of Neurosurgery, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China;[4]Department of Infectious Diseases, Tangshan Workers' Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China;[5]Department of Radiology, Tangshan Workers' Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2011年第6卷第7期,共6页高影响力期刊 基　　金：the Science and Technology Support Program of Hebei Province in 2009, No. 09276101D-10 摘　　要：Exogenous stem cell transplantation and endogenous stem cell mobilization are both effective for the treatment of acute cerebral infarction. The compound dl-3-butylphthalide is known to improve microcirculation and help brain cells at the infarct loci. This experiment aimed to investigate the effects of dl-3-butylphthalide intervention based on the transplantation of hematopoietic stem cells and mobilization of endogenous stem cells in a rat model of cerebral infarction, following middle cerebral artery occlusion. Results showed that neurological function was greatly improved and infarct volume was reduced in rats with cerebral infarction. Data also showed that dl-3-butylphthalide can promote hematopoietic stem cells to transform into vascular endothelial cells and neuronal-like cells, and also enhance the therapeutic effect on cerebral infarction by hematopoietic stem cell transplantation and endogenous stem cell mobilization. 关 键 词：造血干细胞移植 治疗效果 脑梗塞 内源性 苯酞 丁基 神经元样细胞 血管内皮细胞
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