Pathogenesis of occult chronic hepatitis B virus infection

查看全文 作　　者：Rocio Aller de la [1,2]Fuente;María L [3]Gutiérrez;Javier Garcia-[4]Samaniego;Conrado Fernández-[3]Rodriguez;Jose Luis [3]Lledó;Gregorio [5]Castellano

机构地区：[1]Gastroenterology,Hospital Clinico Universitario Valladolid;[2]Institute of endocrinology and Nutrition,Medical School,University of Valladolid,47003 Valladolid,Spain;[3]Service of Gastroenterology,Hospital Universitario Fundación Alcorcón,Av Budapest-1,28922 Alcorcón,Madrid,Spain;[4]Gastroenterology Department,Hospital Carlos III,c/Sinesio Delgado,28029 Madrid,Spain;[5]Hospital Universitario 12 de Octubre,Av de Andalucia 28041,28039 Madrid,Spain

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第12期,共6页

摘　　要：Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns.Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene expression.OBI is an entity with world-wide diffusion.The failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this'occult'HBV infection;although the mechanisms responsible for suppression of HBV are not well understood.The majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV infection.Much evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma. 关键词：秘密肝炎 B 病毒感染肝炎 B virus-DNA Anti-HBc 独自一个肝炎 B 病毒 Hepadnaviral 肝炎秘密病毒的坚持主要秘密感染第二等的秘密感染病毒复活

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Pathogenesis of occult chronic hepatitis B virus infection

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