Clinical significance of serum expression of GROβ in esophageal squamous cell carcinoma

查看全文 作　　者：Qiao-Mei [1]Dong;Jin-Qiang [1]Zhang;Qian [1]Li;Jacqueline C [3]Bracher;Denver T [3]Hendricks;Xiao-Hang [1,2]Zhao

机构地区：[1]State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;[2]Center of Basic Medical Sciences, Navy General Hospital, Beijing 100048, China;[3]Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第21期,共5页

基　　金：Supported by The Grants from International Science & Technology Cooperation and Exchange Programs, No. 2008DFA31130;Joint China/South Africa Science and Technology Agreement;National Natural Science Foundation of China, No. 81021061, No. 0772507 and No. 30700992;State Key Projects for Basic Research of China, No. 2011CB910703 摘　　要：AIM:To determine the association between serum levels of growth-related gene product β(GROβ) and clinical parameters in esophageal squamous cell carcinoma(ESCC).METHODS:Using enzyme-linked immunosorbent assay,serum GROβ levels were measured in ESCC patients(n = 72) and healthy volunteers(n = 83).The association between serum levels of GROβ and clinical parameters of ESCC was analyzed statistically.RESULTS:The serum GROβ levels were much higher in ESCC patients than in healthy controls(median:645 ng/L vs 269 ng/L,P < 0.05).Serum GROβ levels were correlated positively with tumor size,lymph node metastasis,and tumor-node-metastasis(TNM) staging,but not with gender or the histological grade of tumors in ESCC patients.The sensitivity and specificity of the assay for serum GROβ were 73.61% and 56.63%,respectively.CONCLUSION:GROβ may function as an oncogene product and contribute to tumorigenesis and metastasis of ESCC. 关键词：鳞状细胞癌临床意义食管癌血清酶联免疫吸附试验基因产物统计学分析淋巴结

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Clinical significance of serum expression of GROβ in esophageal squamous cell carcinoma

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