Mouse models of medulloblastoma

查看全文 作　　者：Paul [1]A.Northcott;Sidney [1]Croul;Michael [1]D.Taylor

机构地区：[1]Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children

出　　处：《Chinese Journal of Cancer》索引2011年第30卷第7期,共8页

摘　　要：Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including cancer, and serve a valuable role as preclinical models for testing targeted therapies. In this review, we summarize how such models have been successfully applied to the study of medulloblastoma over the past decade and what we might expect in the coming years. 关键词：小鼠模型母细胞遗传工程人类疾病脑肿瘤发病率小儿神经

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Mouse models of medulloblastoma

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