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Over-expression of Metastasis-associated in Colon Cancer-1 (MACC1) Associates with Better Prognosis of Gastric Cancer Patients

查看全文 作　　者：Shao-hua [1]Ge;Xiao-jiang [1]Wu;Xiao-hong [1]Wang;Xiao-fang [1]Xing;Lian-hai [1]Zhang;Yu-bing [1]Zhu;Hong [1]Du;Bin [2]Dong;Ying [3]Hu;Jia-fu [1]Ji 高影响力作者 机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), 1Department of Gastrointestinal Surgery;[2]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),Department of Pathology,;[3]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),Tissue Bank, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2011年第23卷第2期,共7页高影响力期刊 基　　金：supported by the grants of the Foundation from Beijing Municipal Committee of Science and Technology (No. D0905001040631);the Scientific Research Foundation for the Returned Overseas Chinese Scholars from Ministry of Education of China 摘　　要：Objective: The aim of this study was to detect metastasis-associated in colon cancer-1 (MACC1) expression in Chinese gastric cancer and analyze the relationship between MACC1 expression and postoperative survival. Methods: The expression of MACC1 and c-MET protein in a sample of 128 gastric cancer tissues was detected by immunohistochemistry. A retrospective cohort study on the prognosis was carried out and data were collected from medical records. Results: The positive rate of MACC1 protein expression in gastric cancer was 47.66%, higher than that in adjacent noncancerous mucosa (P<0.001). MACC1 protein expression was not related to the clinicopathological variables involved. Kaplan-Meier analysis revealed that the survival of MACC1 positive group tended to be better than that of MACC1 negative group, particularly in patients with stage III carcinoma (P=0.032). Cox regression analysis revealed that MACC1 protein over-expression in gastric cancer tended to be a protective factor with hazard ratio of 0.621 (P=0.057). Immunohistochemical analysis showed that the positive rate of c-MET protein expression was much higher in cases with positive MACC1 expression in gastric cancer (P=0.002), but P53 expression was not associated with MACC1 expression. Conclusion: MACC1 over-expression implies better survival and may be an independent prognostic factor for gastric cancer in Chinese patients. 关 键 词：过度表达 结肠癌 胃癌 预后 患者 移相 蛋白表达 化学检测
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