Hox Gene Clusters of Early Vertebrates:Do They Serve as Reliable Markers for Genome Evolution?

查看全文 作　　者：Shigehiro [1]Kuraku

机构地区：[1]Laboratory for Zoology and Evolutionary Biology Department of Biology University of Konstanz,78464 Konstanz Germany

出　　处：《Genomics, Proteomics & Bioinformatics》索引2011年第9卷第3期,共7页

基　　金：supported by the Young Scholar Fund from University of Konstanz and grants from German Research Foundation(KU2669/1-1) 摘　　要：Hox genes,responsible for regional specification along the anteroposterior axis in embryogenesis,are found as clusters in most eumetazoan genomes sequenced to date.Invertebrates possess a single Hox gene cluster with some exceptions of secondary cluster breakages, while osteichthyans (bony vertebrates) have multiple Hox clusters. In tetrapods, four Hox clusters,derived from the so-called two-round whole genome duplications (2R-WGDs),are observed.Overall,the number of Hox gene clusters has been regarded as a reliable marker of ploidy levels in animal genomes. In fact, this scheme also fits the situations in teleost fishes that experienced an additional WGD. In this review, I focus on cyclostomes and cartilaginous fishes as lineages that would fill the gap between invertebrates and osteichthyans.A recent study highlighted a possible loss of the HoxC cluster in the galeomorph shark lineage, while other aspects of cartilaginous fish Hox clusters usually mark their conserved nature. In contrast,existing resources suggest that the cyclostomes exhibit a different mode of Hox cluster organization.For this group of species,whose genomes could have differently responded to the 2R-WGDs from jawed vertebrates,therefore the number of Hox clusters may not serve as a good indicator of their ploidy level. 关键词：HOX基因无脊椎动物基因组进化基因簇标记早期软骨鱼类基因组测序

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Hox Gene Clusters of Early Vertebrates:Do They Serve as Reliable Markers for Genome Evolution?

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