Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cell transplantation improves hypoxic-ischemic brain injury

查看全文 作　　者：Dengna [1]Zhu;Yanjie [2]Jia;Jun [1]Wang;Boai [2]Zhang;Guohui [1]Niu;Yazhen [1]Fan

机构地区：[1]Rehabilitation and Treatment Center for Children with Cerebral Palsy of Henan Province, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China;[2]Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China

出　　处：《Neural Regeneration Research》索引2011年第6卷第19期,共7页

基　　金：the National Natural Science Foundation of China, No.30770758, 81071114 摘　　要：Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cells were transplanted into a hypoxic-ischemic neonatal rat model via the tail vein. BrdU-positive cells at day 7 post-transplantation, as well as nestin- and neuron specific enolase-positive cells at day 14 were increased compared with those of the single neural stem cell transplantation group. In addition, the proportion of neuronal differentiation was enhanced. The genetically modified cell-transplanted rats exhibited enhanced performance in correctly crossing a Y-maze and climbing an angled slope compared with those of the single neural stem cell transplantation group. These results showed that human insulin-like growth factor 1-transfected neural stem cell transplantation promotes the recovery of the learning, memory and motor functions in hypoxic-ischemic rats. 关键词：胰岛素样生长因子1 神经干细胞移植缺氧缺血神经元特异性烯醇化酶转染脐血脑损伤缺氧性

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Human insulin-like growth factor 1-transfected umbilical cord blood neural stem cell transplantation improves hypoxic-ischemic brain injury

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