Triptolide protects astrocytes from hypoxia/reoxygenation injury

查看全文 作　　者：Minfang [1]Guo;Hongcui [1]Fan;Jiezhong [1]Yu;Ning [1]Ji;Yongsheng [1]Sun;Liyun [1]Liang;Baoguo [1,2]Xiao;Cungen [1]Ma

机构地区：[1]Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037008, Shanxi Province, China;[2]Institute of Neurology, Huashan Hospital, Fudan University, Shanghai 200025, China

出　　处：《Neural Regeneration Research》索引2011年第6卷第21期,共5页

基　　金：the National Natural Science Foundation of China, No.81070957;the Natural Science Foundation of Shanxi Province, No.2008011082-1 摘　　要：Astrocytes in an in vitro murine astrocyte model of oxygen and glucose deprivation/hypoxia and reoxygenation were treated with different concentrations of triptolide (250, 500, 1 000 ng/mL) in a broader attempt to elucidate the protection and mechanism underlying triptolide treatment on astrocytes exposed to hypoxia/reoxygenation injury. The results showed that the matrix metalloproteinase-9, interleukin-1β, tumor necrosis factor α and interleukin-6 expressions were significantly decreased after triptolide treatment in the astrocytes exposed to hypoxia/ reoxygenation injury, while interleukin-10 expression was upregulated. In addition, the vitality of the injured astrocytes was enhanced, the triptolide's effect was apparent at 500 ng/mL. These experimental findings indicate that triptolide treatment could protect astrocytes against hypoxia/ reoxygenation injury through the inhibition of inflammatory response and the reduction of matrix metalloproteinase-9 expression. 关键词：缺氧/复氧损伤星形胶质细胞雷公藤甲素保护基质金属蛋白酶白细胞介素1 肿瘤坏死因子细胞缺氧

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Triptolide protects astrocytes from hypoxia/reoxygenation injury

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