Photoproducts of tetracycline and oxytetracycline involving self-sensitized oxidation in aqueous solutions:Effects of Ca^(2+) and Mg^(2+)

查看全文 作　　者：Yong [1]Chen;Hua [1]Li;Zongping [1]Wang;Tao [1]Tao;Chun [2]Hu

机构地区：[1]School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;[2]State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China

出　　处：《Journal of Environmental Sciences》索引2011年第23卷第10期,共6页

基　　金：supported by the National Natural Science Foundation of China (No. 21007018,51078161);the Natural Science Foundation of Hubei Province (No. 2010CDB01104);the Research Fund for the Doctoral Program of Higher Education of China (No. 20100142120004);the 11th Five-year Plan of National Water Environmental Special Program of China (No. 2008ZX07211-10-02) 摘　　要：Tetracyclines constitute one of the most important antibiotic families and represent a classic example of phototoxicity.The photoproducts of tetracyclines and their parent compounds have potentially adverse effects on natural ecosystem.In this study,the self-sensitized oxidation products of tetracycline (TC) and oxytetracycline (OTC) were determined and the effects of Ca2+ and Mg2+ on self-sensitized degradation were investigated.The Ca2+ and Mg2+ in the natural water sample accounted for enhancement (pH 7.3) and inhibition (pH 9.0) of photodegradation of TC and OTC due to the formation of metal-ions complexes.The formation of Mg2+ complexes was unfavorable for the photodegradation of the tetracyclines at both pH values.In contrast,the Ca2+ complexes facilitated the attack of singlet oxygen (1O2) arising from self-sensitization at pH 7.3 and enhanced TC photodegradation.For the first time,selfsensitized oxidation products of TC and OTC were verified by quenching experiments and detected by LC/ESI-DAD-MS.The products had a nominal mass 14 Da higher than the parent drugs (designated M+14),which resulted from the 1O2 attack of the dimethylamino group on the C-4 atom of the tetracyclines.The presence of Ca2+ and Mg2+ also affected the generation of M+14 due to the formation of metal-ions complexes with TC and OTC.The findings suggest that the metal-ion complexation has significant impact on the selfsensitized oxidation processes and the photoproducts of tetracyclines. 关键词：氧化产物四环素土霉素水溶液自然生态系统金属离子 OTC pH值

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Photoproducts of tetracycline and oxytetracycline involving self-sensitized oxidation in aqueous solutions:Effects of Ca^(2+) and Mg^(2+)

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引证文献(15)

耦合文献(41)

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