维普中文期刊产品整合服务

Optimization of an in vitro method to measure the bioaccessibility of polybrominated diphenyl ethers in dust using response surface methodology

查看全文 作　　者：Yingxin [1,2]Yu;Yuping [2]Pang;Xinyu [2]Zhang;Chen [2]Li;Zhiqiang [1]Yu;Jiamo [1,2]Fu 高影响力作者 机构地区：[1]State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China;[2]Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China高影响力机构 出　　处：《Journal of Environmental Sciences》索引2011年第23卷第10期,共9页高影响力期刊 基　　金：supported by the National Basic Research Program (973) of China (No. 2008CB418205);the Earmarked Fund of the State Key Laboratory of Organic Geochemistry (No. OGL-200903);the National Nature Science Foundation of China (No. 20807026,40830744);the Shanghai Leading Academic Disciplines (No. S30109) 摘　　要：To more reasonably evaluate human intake of PBDEs via dust ingestion,bioaccessibility should be taken into account.Previously,we developed an in vitro method to determine the bioaccessibility of PBDEs in food.Here,this method was adapted to determine the bioaccessibility of PBDEs in dust and the digestion conditions that influenced the bioaccessibility of PBDEs were optimized.The digestion conditions included the incubation time of dust in the intestinal digestion solution (T),the bile concentration in the intestinal digestion solution (C bile),and the ratio of the volume of the intestinal digestion solution to dust (R).The influence of the concentrations of individual PBDE congeners (C PBDE) on the bioaccessibility of PBDEs was also investigated.Central composite design was used to build an experimental model and set experimental parameters,and response surface methodology was used to analyze the obtained data.The results showed that the bioaccessibility of PBDEs increased with the increases of C bile and R,and was independent of T and C PBDE.Under the digestion conditions with C bile and R being at 4.0-7.0 g/L and 150-250,respectively,the bioaccessibility of PBDEs in the method-dust varied from 39.2% to 72.8%,which were comparable with the bioaccessibility or bioavailability of PBDEs in dust/soil in the literature.Thus,the in vitro method to measure the bioaccessibility of PBDEs in dust was established and validated.Finally,the bioaccessibility of PBDEs in four natural dust samples,which ranged from 36.1% to 43.3%,were determined using the adapted method. 关 键 词：生物有效性 响应曲面法 多溴联苯醚 灰尘 体外 优化 PBDES 多溴二苯醚
相关文献

参考文献(39)

引证文献(2)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费