A near-infrared fluorescent probe for fluorine ions and its application in the imaging of HepG2 cells

查看全文 作　　者：GONG Wei SU RuiXian LI Lu XU KeHua TANG [1]Bo

机构地区：[1]Key Laboratory of Molecular and Nano Probes of Ministry of Education, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production of Ministry of Education, College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China

出　　处：《Chinese Science Bulletin》索引2011年第56卷第31期,共6页

基　　金：supported by the National Basic Research Program of China (2007CB936000);the National Natural Science Foundation of China (20875057);the National Natural Science Funds for Distinguished Young Scholar (20725518);the National Key Natural Science Foundation of China (21035003);the Science and Technology Development Programs of Shandong Province of China (2008GG30003012);the Key Natural Science Foundation of Shandong Province of China (ZR2010BZ001) 摘　　要：In this study, we have designed and synthesized a new near-infrared (NIR) fluorescent probe (BODIPY-Se) to detect fluorine ions (F-) using a B-Se bond to connect the fluorescent dye BODIPY and benzotrifluoride. The probe exhibited a highly selective fluorescence response to F- with a detection limit of 7.4×108 mol/L. The excitation and emission spectra of the probe in the NIR region avoid background fluorescence interference present in biological systems. The fluorescent imaging of HepG2 cells demonstrated that the newly developed probe should be broadly applicable to detect F- in living cells. 关键词：HEPG2细胞荧光探针近红外氟离子细胞成像应用肾上腺素荧光染料

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A near-infrared fluorescent probe for fluorine ions and its application in the imaging of HepG2 cells

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