Effects of chitosan-TPP nanoparticles on hepatic tissue after severe bleeding

查看全文 作　　者：Zhao [1]Aiyuan;Wang [1]Taoyuan;Yao [2]Mini;Li [1]Hongwei

机构地区：[1]IDepartment of Scientific Research, Medical College of Chinese People "s Armed Police Forces, Tianjin 300162, China;[2]Department of internal medicine Tianjin Corps Hospital of Chinese People's Armed Police Forces, Tianjin 300163, China

出　　处：《Journal of Medical Colleges of PLA(China)》索引2011年第26卷第5期,共10页

摘　　要：Recently, chitosan nanoparticles have been an attractive biomaterial for their unique properties. Chitosan nanoparticles are mainly used as drug delivers. However, they are seldom used in wound healing after severe bleeding. In the present paper, chitosan nanoparticles with an average size of 60.2 nm were prepared through ionic gelation and characterized by X-ray diffraction and FT-infrared spectrometry. A new animal model of severe bleeding was made to evaluate its effects on wound healing besides hemostasis. The results showed that it can achieve well hemostatic effects and also induce wound healing after severe bleeding. Blood cells can be absorbed by chitosan nanoparticles and the bleeding is treated. Furthermore, the chitosan nanoparticles sustains longer than other materials in wound healing. At the 15th day after operation, the chitosan nanoparticles with the size of 58.3 nm can still be seen in the new-regenerated hepatic tissue. It can induce the formation of a clear granulation around the wound site. Through histological observation, we find out that chitosan-TPP nanoparticles can induce wound healing through migration of the inflammatory cells and synthesis of collagen. So, chitosan nanoparticles show us both hemostasis and the ability of wound healing for parenchymal organs. 关键词：纳米粒子壳聚糖 TPP 肝组织出血伤口愈合止血效果红外光谱特征

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Effects of chitosan-TPP nanoparticles on hepatic tissue after severe bleeding

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