Antioxidants in aqueous extract of Myristica fragrans(Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L.cells

查看全文 作　　者：Akeem [1]AKINBORO;Kamaruzaman Bin [1]MOHAMED;Mohd Zaini [2]ASMAWI;Shaida Fariza [1]SULAIMAN;Othman Ahmad [1]SOFIMAN

机构地区：[1]School of Biological Sciences,Universiti Sains Malaysia;[2]School of Pharmaceutical Sciences,Universiti Sains Malaysia

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》索引2011年第12卷第11期,共8页

摘　　要：In this study,freeze-dried water extract from the leaves of Myristica fragrans(Houtt.) was tested for mutagenic and antimutagenic potentials using the Allium cepa assay.Freeze-dried water extract alone and its combination with cyclophosphamide(CP)(50 mg/kg) were separately dissolved in tap water at 500,1000,2000,and 4000 mg/kg.Onions(A.cepa) were suspended in the solutions and controls for 48 h in the dark.Root tips were prepared for microscopic evaluation.2,2-Diphenyl-1-picrylhydrazyl(DPPH) free radicals' scavenging power of the extract was tested using butylated hydroxyanisole(BHA) and butylated hydroxytoluene(BHT) as standards.Water extract of Myristica fragrans scavenged free radicals better than BHA,but worse than BHT.The extract alone,as well as in combination with CP suppressed cell division,and induced chromosomal aberrations that were insignificantly different from the negative control(P≤0.05).However,cytotoxic and mutagenic actions of CP were considerably suppressed.The observed effects on cell division and chromosomes of A.cepa may be principally connected to the antioxidant properties of the extract.The obtained results suggest mitodepressive and antimutagenic potentials of water extract of the leaves of M.fragrans as desirable properties of a promising anticancer agent. 关键词：瞀或蒜之类 cepa 抗氧化剂 Chromosomal 错误 CYCLOPHOSPHAMIDE 有丝分裂的索引

相关文献

参考文献（37）
引证文献（4）
耦合文献（2）

参考文献(37)

引证文献(4)

耦合文献(2)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Antioxidants in aqueous extract of Myristica fragrans(Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L.cells

参考文献(37)

引证文献(4)

耦合文献(2)

用户提示