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Ganoderma lucidum spore powder modulates Bcl-2 and Bax expression in the hippocampus and cerebral cortex,and improves learning and memory in pentylenetetrazole-kindled rats

查看全文 作　　者：Shuang [1]Zhao;Shengchang [2]Zhang;Shuqiu [3]Wang 高影响力作者 机构地区：[1]Department of Pathophysiology, Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China;[2]Department of Human Anatomy, Basic Medical College, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;[3]Department of Pathophysiology, Basic Medical College of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2011年第6卷第30期,共5页高影响力期刊 基　　金：Grant from Research Funds of Education Department of Guangxi Zhuang Autonomous Region, No. 200810LX340; Youjiang Medical College for Nationalities, No. 0802002 摘　　要：We studied the effects of Ganoderma lucidum spore powder on Bax and Bcl-2 expression and neuronal apoptosis in pentylenetetrazole-kindled epileptic rats.Sixty adult rats were randomly divided into a control group,an epileptic group (kindled) and three medication groups (150,300,450 mg/kg given to kindled rats).Bax and Bcl-2 immunohistochemistry and TUNEL labeling showed that the number of Bax-and TUNEL-positive cells in the hippocampus and cerebral cortex decreased significantly in the high-dose medication group,while the number of Bcl-2 immunoreactive cells increased.The Morris water maze test showed that high-dose treatment significantly shortened escape latency and increased spatial probe trial performance.Our findings indicate that a high dose of Ganoderma lucidum spore powder upregulates the expression of antiapoptotic Bcl-2 protein in the hippocampus and cerebral cortex,inhibits proapoptotic Bax expression,and decreases seizure-induced neuronal apoptosis.Further,Ganoderma lucidum appears to protect against epilepsy-related learning and memory impairments. 关 键 词：BAX蛋白 灵芝孢子粉 成年大鼠 大脑皮质 戊四氮 点燃 海马 记忆能力
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