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Seropositivity rates of water channel protein 4 antibodies compared between a cell-based immunofluorescence assay and an enzyme-linked immunosorbent assay in neuromyelitis optica patients

查看全文 作　　者：Xiaoli [1]Wu;Zhangyuan [2]Liao;Jing [2]Ye;Huiqing [2]Dong;[1]ChaodongWang;Piu [1]Chan 高影响力作者 机构地区：[1]Department of Neurology and Key Laboratory Ministry of Education on Neurodegenerative Diseases, Xuanwu Hospital of Capital MedicalUniversity, Beijing 100053, China;[2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China高影响力机构 出　　处：《Neural Regeneration Research》索引2011年第6卷第32期,共5页高影响力期刊 基　　金：the grants from the Ministry of Sciences and Technology of China, No. 2006AA02A408, 2008ZX09312-014 摘　　要：A total of 66 samples (from 27 cases with neuromyelitis optica, 26 cases with multiple sclerosis, and 13 cases with optic neuritis) were tested for aquaporin-4 antibody by a cell-based immunofluores-cence assay and an enzyme-linked immunosorbent assay. The sensitivities and specificities of the two assays were similar. We further analyzed an additional 68 patients and 93 healthy controls using the enzyme-linked immunosorbent assay. A Kappa test showed good consistency between the two methods in terms of detection of anti-aquaporin-4 antibody in the sera of neuromyelitis optica patients. No significant correlations were identified with onset age or disease duration, suggesting that aquaporin-4 antibody is a good marker for neuromyelitis optica. The enzyme-linked immu-nosorbent assay can be used for quantifying aquaporin-4 antibody concentrations and may be useful to dynamically monitor changes in the levels of aquaporin-4 antibody during disease duration. 关 键 词：酶联免疫吸附试验 水通道蛋白4 免疫荧光法 抗体检测 脊髓炎 视神经 患者 细胞
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