FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus

查看全文 作　　者：Keyur [1]Patel;Mireen Friedrich-[2]Rust;Yoav [3]Lurie;Mircea [4]Grigorescu;Carol [5]Stanciu;Chuan-Mo [6]Lee;Eugene R [7]Schiff;Dieter H[8]ussinger;Michael P [9]Manns;Guido [9]Gerken;Isabelle [10]Colle;Michael [11]Torbenson;Erik [12]Pulkstenis;G Mani [13]Subramanian;John G [1]McHutchison;Stefan [2]Zeuzem

机构地区：[1]Department of Gastroenterology and Hepatology,Duke Clinical Research Institute;[2]Department of Gastroenterology and Hepatology,J.W.Goethe University Hospital;[3]Department of Gastroenterology and Hepatology,Tel Aviv Sourasky Medical Center;[4]Department of Clinical Infectious Disease,Spitalul Clinic de Urgenta;[5]Department of Gastroenterology and Hepatology,Institutul de Gastroenterologie si Hepatologie;[6]Department of Gastroenterology,Chang Gung Memorial Hospital-Kaohsiung Medical Center,Chang Gung University College of Medicine;[7]Departments of Gastroenterology and Internal Medicine,University of Miami;[8]Department of Gastroenterology and Hepatology,Universittsklinik;[9]Department of Gastroenterology and Hepatology;[10]Department of Gastroenterology and Hepatology,Ghent University Hospital;[11]Department of Pathology,Johns Hopkins University School of Medicine;[12]Department of Biostatistics,Human Genome Sciences;[13]Department of Clinical Research,Human Genome Sciences

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第41期,共9页

基　　金：Supported by Human Genome Sciences and Novartis Pharma AG,Basel,Switzerland 摘　　要：AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. 关键词：丙型肝炎病毒治疗慢性 TM 评估基准亚洲人工作曲线 TE

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FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus

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