Pancreatic cancer risk variant ABO rs505922 in patients with cholangiocarcinoma

查看全文 作　　者：Marcin [1]Krawczyk;Florentina [1,2]Mihalache;Aksana H[3]blinger;Monica [2]Acalovschi;Frank [1]Lammert;Vincent [1]Zimmer 机构地区：[1]Department of Medicine Ⅱ,Saarland University Medical Center;[2]Department of Medicine Ⅲ,University Iuliu Hatieganu;[3]Department of Internal MedicineⅠ,University Hospital Bonn 出　　处：《World Journal of Gastroenterology》索引2011年第17卷第41期,共3页 摘　　要：The aim of this study was to investigate an association between the development of cholangiocarcinoma(CCA)and the ABO variant rs505922(known to increase pan-creatic cancer risk)in a large cohort of European individuals with CCA.In total,180 individuals with CCA and 350 CCA-free controls were included.The ABO variant rs505922 was genotyped using a polymerase chain reaction-based assay.Association between this single nucleotide polymorphism(SNP)and CCA was tested in contingency tables.Neither allele distributions nor association tests and regression analysis provided evidence for an increased risk of CCA among carriers of the ABO variant(all P > 0.05).Nevertheless,we documented a deviation from Hardy-Weinberg equilibrium in the entire CCA cohort(P = 0.028)and for patients with intrahe-patic(P = 0.037)but not extrahepatic tumor localization(P > 0.05).The association tests did not provide evidence for a prominent role of the investigated SNP in the genetic risk of CCA.However,Hardy-Weinberg disequilibrium in the entire cohort and the intrahepatic CCA subgroup warrants future studies investigating a potential CCA risk modulation by individual blood groups. 关 键 词：ABO血型 潜在风险 Hardy-Weinberg平衡 变异 癌症 患者 胆管 单核苷酸多态性