Epidemiological aspects of Budd-Chiari in Egyptian patients:A single-center study

查看全文 作　　者：Mohammad [1]Sakr;Eman [1]Barakat;Sara [1]Abdelhakam;Hany [1]Dabbous;Said [2]Yousuf;Mohamed [3]Shaker;Ahmed [3]Eldorry

机构地区：[1]Department of Tropical Medicine,Faculty of Medicine,Ain Shams University,Abbassia;[2]Department of Hematology,Faculty of Medicine,Ain Shams University;[3]Department of Radiodiagnosis and Interventional Radiology,Faculty of Medicine,Ain Shams University

出　　处：《World Journal of Gastroenterology》索引2011年第17卷第42期,共7页

摘　　要：AIM:To describe the socio-demographic features,etiology,and risk factors for Budd-Chiari syndrome(BCS) in Egyptian patients.METHODS:Ninety-four Egyptian patients with confirmed primary Budd-Chiari syndrome were presented to the Budd-Chiari Study Group(BCSG) and admitted tothe Tropical Medicine Department of Ain Shams University Hospital(Cairo,Egypt) . Complete clinical evaluation and laboratory investigations,including a throm bophiliaworkup and full radiological assessment,were performed to determine underlying disease etiologies.RESULTS:BCS was chronic in 79.8% of patients,acute or subacute in 19.1%,and fulminant in 1.1%.Factor V Leiden mutation(FVLM) was the most common etiological cause of disease(53.1%) ,followed by mutation of the gene encoding methylene tetra-hydrofolate reductase(MTHFR) (51.6%) . Current orrecent hormonal treatment was documented in 15.5%of females,and BCS associated with pregnancy was present in 17.2% of females. Etiology could not be determined in 8.5% of patients. Males had significantly higher rates of MTHFR gene mutation and Beh et's disease,and females had significantly higher ratesof secondary antiphos pholipid antibody syndrome.A highly significant positive relation ship was evident between the presence of Beh et's disease and inferiorven a caval occlusion,either alone or combined with occlusion of the hepatic veins(P < 0.0001) .CONCLUSION:FVLM is the most common disease etiology and MTHFR the second most common in Egyptian BCS patients. BCS etiology tends to vary with geographic region. 关键词：患者埃及流行病学亚甲基四氢叶酸还原酶 MTHFR 基因突变 BCS 凝血因子V

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Epidemiological aspects of Budd-Chiari in Egyptian patients:A single-center study

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